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differential management classification disease lupus sle erythematosus hematology signs symptoms autoimmune behcet cll comparison cryoglobulinemia cryoglobulins druginduced igg4 laboratory leukemia
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
central nervous system ... - systemic ... induced by chronic ... #Rheumatology # ... Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... Eosinophilia, asthma, chronic ... : • Behçet Syndrome ... • Cogan Syndrome ... #rheumatology #
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... association • M > F Clinical ... (Clinical Dx). ... Recurrent and chronic ... signs #symptoms #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... Demyelinating syndromes ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... ) Autoantibodies ... Evans • ITP • Cl-NH ... #Differential #Diagnosis ... #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... Clinical Features ... with Lupus: • Chronic ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... Eosinophilia, asthma, chronic ... • Cogan syndrome ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... : • Clinical triad ... • Autoimmune diseases ... Labs/Diagnosis: ... classification #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history ... female, asian • Systemic ... No necrosis, No vasculitis ... #phenotypes #workup ... #treatment #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... months to years) Systemic ... • Evolution: Chronic ... disease Dr. ... #diagnosis #management
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