12 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Scurvy - Actinic damage ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology ... #rheumatology #
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
disorders • Diagnosis ... and Treatment Algorithm ... #HES #Hematology ... eosinophils #diagnosis #management ... #algorithm
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Petechiae/Purpura ... - Diagnostic Algorithm ... vasculitis) or disorders ... #Rash #Petechiae ... #Ddxof
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
and end-organ damage ... Arthralgia - Purpura ... triad of Palpable purpura ... Henoch-Schönlein purpura ... classification #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
easy bruising to purpura ... (Petechial or purpuric ... rash) • Heart, ... #Diagnosis #Management ... #Hematology #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
lesions, palpable purpura ... uveitis or retinal damage ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... WBC >100k, + lab signs ... of end organ damage ... TLS #diagnosis #management ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
mucositis - Rash ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... : strong sign of ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: Strong sign of ... , mucositis • Rash ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology