11 results
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
in vasculitic diseases ... disseminated gonococcal disease ... or purpuric rash ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
, Palpable purpura ... Maculopapular rash ... • Palpable purpura ... • Goodpasture syndrome ... #rash #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... mucosal bleeding (Petechial ... or purpuric rash ... Diagnosis #Management #Hematology ... #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Clinical triad of Palpable ... • Autoimmune diseases ... diagnosis #types #classification ... #rheumatology #
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... hemolytic-uremic syndrome ... central nervous system ... alopecia, purpura, palpable ... vesicular rash,
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
mucositis - Rash ... • Cogan Syndrome ... scleritis • Palpable ... Skin -> causing palpable ... #classification
Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Hypertension - BP > 140/90 (>130/80 for DM)
Hypertensive urgency
Differential Diagnosis Algorithm ... with end-organ damage ... Renal Parenchymal Diseases ... • Bilateral RAS ... Sympathetic nervous system
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... Malignancy (e.g. hematologic ... Neuropsychiatric systemic ... vein thrombosis Hematologic
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Mucocutaneous lymph node syndrome ... , mucositis • Rash ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... Systemic disease ... multiforme-like lesions, palpable ... uveitis or retinal damage ... signs #symptoms #rheumatology