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diagnosis causes coagulation abnormal aptt prolonged rheumatology thrombocytopenia acronym activation algorithm bleeding bruising chemistry dic disorders disseminated hemostasis interpretation intravascular
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT ... hemosiderin • PT ... #Algorithm #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
selected cases: INR/PT ... changes), high MCV anemia ... gastric bypass), LFT ... (liver disease) ... Causes #Workup #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... • Reduced liver ... #hematology #coagulation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Coagulation factors: PT ... replaced by non-hepatic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... unfractionated heparin ... Reduced liver synthesis ... Causes #diagnosis #differential ... #hematology #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... deficiency • Liver ... #Diagnosis #hematology ... #nonpalpable #dermatology
PLATELETS Mnemonic for Causes of Thrombocytopenia P - Platelet Disorders (DIC, ITP, TTP) L - Leukemia, Lymphoma A -
A - Aplastic Anemia ... Enlarged Spleen L - Liver ... Toxin (Drug or Heparin-induced ... Thrombocytopenia #Differential ... #Diagnosis #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... causes #treatment #management ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Acquired: • Heparin ... deficiency • Liver ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
with leukopenia, anemia ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
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