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obstetrics aflp causes obgyn pregnancy chemistry coagulation comparison disseminated fatty hellp injury interpretation intravascular lfts pathophysiology pph rvalue transaminitis treatment
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... Hepatic infarcts, Hematomas ... #hepatology #obstetrics ... #differential # ... diagnosis #icp #
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
range: 18 wks - postpartum ... rapidly develops (DIC ... infiltration) Differential ... Hepatitis, Preeclampsia ... #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... hemolysis, bleeding, hematoma ... diagnosis #algorithm ... #hepatology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Diagnosis Algorithm ... Vaginal laceration / hematoma ... von Willebrand's disease ... Hemophilia A) #PostPartum ... Diagnosis #Algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
disease: > 2 ... hemolysis, bleeding, hematoma ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Subcutaneous dissecting hematoma ... • Severe Liver ... Disease: - Impaired ... #Coagulation #diagnosis ... #hematology
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