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diagnosis aflp hepatitis obstetrics coagulation comparison disease disseminated fatty hellp injury intravascular obgyn pathophysiology treatment
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Hepatic infarcts, Hematomas ... extensive necrosis and hemorrhage ... DIC • Aminotransferases ... #hepatology #obstetrics ... hepatitis #comparison #differential
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... rapidly develops (DIC ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... #Pregnancy #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Acral cyanosis • Hemorrhagic ... Subcutaneous dissecting hematoma ... • Severe Liver ... #treatment #management ... #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Vascular Causes ... melanoma, myeloma • Pregnancy ... hemolysis, bleeding, hematoma ... #hepatology
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