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aflp obstetrics coagulation comparison dermatology disease disseminated hellp hepatitis intravascular obgyn pathophysiology purpura rheumatology treatment
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Hepatic infarcts, Hematomas ... Acute Fatty Liver ... DIC • Aminotransferases ... #hepatology #obstetrics ... #diagnosis #icp
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... rapidly develops (DIC ... infiltration) Differential ... #Liver #Pregnancy ... #hepatology #obstetrics
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... red to purple, hemorrhagic ... deficiency • Liver ... #Diagnosis #hematology ... palpable #nonpalpable
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Purpura • Palpable ... Subcutaneous dissecting hematoma ... • Severe Liver ... #Coagulation #diagnosis ... #management #hematology
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