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liver obstetrics aflp algorithm management obgyn pregnancy coagulation comparison disseminated fatty hematology hemorrhage icp injury postpartum pph treatment
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
infarcts, Hematomas ... DIC • Aminotransferases ... #Pregnancy #hepatology ... #obstetrics #hepatitis ... #diagnosis #icp
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... Subcutaneous dissecting hematoma ... • Severe Liver Disease ... #Coagulation #diagnosis
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Vaginal laceration / hematoma ... purpura (TTP) • HELLP ... • Disseminated intravascular ... coagulation (DIC ... von Willebrand's disease
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
rapidly develops (DIC ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Hepatitis, Preeclampsia ... , HELLP, Intrahepatic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... Vascular Causes ... • Pregnancy: HELLP ... hemolysis, bleeding, hematoma ... #hepatology
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