541 results
Key Clinical Points for Rosacea #Management #Derm #PrimaryCare #Rosacea #Overview #TakeHome #NEJM
Rosacea #Management #Derm ... Overview #TakeHome #NEJM
Xanthomas in Familial Hypercholesterolemia #Clinical #PrimaryCare #Derm #Xanthomas #FamilialHypercholesterolemia #Hypercholesterolemia #NEJM
#PrimaryCare #Derm ... Hypercholesterolemia #NEJM
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... siRNA #Therapy #NEJM
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... from albumin upon hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... NonAlcoholicFattyLiverDisease #NEJM
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte
Acanthosis Nigricans and Insulin Resistance - A 27-year-old woman presented with a 2-year history of acanthosis
B) #Clinical #Derm ... Acanthosis #Nigricans #NEJM
Panel A shows a patient with erythematotelangiectatic rosacea, in which diffuse erythema and telangiectasia are present
#Clinical #Derm ... PrimaryCare #Rosacea #NEJM
Excoriated papules with honey-colored crusting were present on the abdomen, back (Panel A), arms, and legs.
#Clinical #Derm ... Microscopy #Rash #NEJM
Crusted Scabies - Physical examination now revealed a generalized erythematous and scaly rash with intense hyperkeratotic
C) #Clinical #Derm ... Scabies #Microscopy #NEJM