16 results
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... #Pathophys #Honc ... siRNA #Therapy #NEJM
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... Pathophysiology #GI #IM ... NonAlcoholicFattyLiverDisease #NEJM
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
stain) #Clinical #HONC ... #Derm #Plasmacytomas ... Leukemia #Smear #NEJM
Ecthyma Gangrenosum - A physical examination revealed a 2-cm hemorrhagic patch with an erythematous border (Panel
#Clinical #Derm ... #Honc #Ecthyma # ... #Neutropenic #NEJM
Squamous-Cell Carcinoma of the Penis with Human Papillomavirus #Clinical #Derm #Honc #Penile #SCC #Glans #HPV #NEJM
Papillomavirus #Clinical #Derm ... #Honc #Penile # ... SCC #Glans #HPV #NEJM
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
used on a long-term ... Pathophysiology #Nephro #IM ... NephronRemodeling #NEJM
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Pathophysiology #Honc ... #IM #Spherocytosis ... HereditarySpherocytosis #NEJM
Upper endoscopy revealed a pigmented mass in the duodenal bulb (Panel A) and two additional masses
#Clinical #GI #Derm ... #Honc #Melanoma ... EGD #Metastatic #NEJM
Immunosuppressive Strategies for the Prevention or Treatment of Acute GVHD. Panel A shows several classic immunosuppressive
Pathophysiology #IM ... #Honc #Pharm #GVHD ... Immunosuppression #NEJM
Diffuse Melanosis Cutis - Several weeks earlier, a progressive gray–blue discoloration of the skin had developed.
#Clinical #Derm ... #Honc #Melanosis ... Hyperpigmentation #NEJM