587 results
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... Pathophysiology #GI #IM ... NonAlcoholicFattyLiverDisease #NEJM
DSM5 Diagnostic Criteria for Delirium #Diagnosis #IM #Delirium #DSM5 #NEJM
Delirium #Diagnosis #IM ... Delirium #DSM5 #NEJM
Approaches to Evaluating Kidney Disease in Patients with HIV Infection #Pathophys #Nephro #IM #HIV #CKD #AKI
Pathophys #Nephro #IM ... HIV #CKD #AKI #NEJM
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... siRNA #Therapy #NEJM
Common Causes of the Different Categories of Dizziness #Diagnosis #PrimaryCare #EM #IM #Differential #Dizziness #Vertigo #Disequilibrium
PrimaryCare #EM #IM ... Lightheadedness #Table #NEJM
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... from albumin upon hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
specimens: ballooned hepatocytes ... HCC #Prevalence #NEJM
Onset of Intramuscular (IM) Medications for Severe Agitation
Ketamine (2-5 mg/kg IM) 3-7m
Droperidol (5 mg IM) 5-10m
Midazolam
Intramuscular (IM ... Ketamine (2-5 mg/kg IM ... Droperidol (5 mg IM ... Lorazepam (5 mg IM ... +2 mg IM) 15-30m
Total-Body Deficits in Chronic Alcohol-Use Disorder. Patients with chronic alcohol-use disorder may have total-body deficits of
#Diagnosis #IM # ... ElectrolyteDisorders #NEJM