26 results
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... #Pathophys #Honc
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... Pathophysiology #GI
Differential Diagnosis of Jaundice, Presentation Pattern #Diagnosis #EM #IM #GI #Jaundice #Pattern #LFTs #Workup #Table #Differential
Diagnosis #EM #IM #GI ... Pattern #LFTs #Workup
Jaundice Evaluation Algorithm #Diagnosis #Management #EM #IM #GI #Jaundice #Hyperbilirubinemia #Workup #Evaluation #Differential #Algorithm #Direct #Indirect
Management #EM #IM #GI ... Hyperbilirubinemia #Workup
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
the extent of hepatocyte ... #Pathophys #Toxicology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Once pseudohypokalemia is ruled out, causes of hypokalemia can be
time (urinary or GI ... Algorithm #Causes #workup
Normal Anion-Gap Acidosis (NAGMA) - Differential Diagnosis Framework and Workup

NAGMA
- Chem, ABG or VBG
- Calculate Anion
Framework and Workup ... hyperchloremia - GI ... GI Loss of HCO3 ... Differential #Diagnosis #Workup
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... FEPO4 < 5%: • GI ... Diagnosis #Framework #Workup
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Mechanism Decreased GI ... hypomagnesemia Excessive GI ... Classification #Causes #Workup
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Differential Diagnosis Workup ... Hypovolemic (H2O loss): GI ... Differential #Diagnosis #Workup