13 results
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
imaging: Normal ... extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... obstetrics #hepatitis #comparison ... #differential #
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... thrombin inhibitors, heparin ... • Reduced liver ... • Massive hemorrhage ... amyloidosis #Abnormal
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... Causes #diagnosis #differential
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... , Metastasis #Liver ... #Lesions #Hepatic ... POCUS #radiology #differential ... #diagnosis #comparison
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... PT/ABNORMAL PTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... 100mg/dL) - Heparin
Mirizzi Syndrome on RUQ POCUS

Adult male-RUQ abd pain.VSS/Afeb. WBC-16.8K. Obstructive pattern on hepatic panel with normal
Obstructive pattern on hepatic ... panel with normal ... Mirizzi's syndrome-Pt ... Mirizzi #Syndrome #Liver ... #POCUS #Ultrasound
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
- If both are normal ... Coagulation factors: PT ... replaced by non-hepatic ... of ALP • Near normal ... chemistry #diagnosis #differential
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage ... - Differential ... Oxytocin 40 IU in 1 liter ... CBC, fibrinogen, PT ... compression (using ultrasound
Appearance of Liver Lesions on Contrast Enhanced Ultrasound - Early arterial, Grayscale phase, Late arterial phase,
Appearance of Liver ... Contrast Enhanced Ultrasound ... #Lesions #Hepatic ... POCUS #radiology #differential ... #diagnosis #comparison