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diagnosis hematology abnormal aptt prolonged aflp bleeding bruising dermatology dic disease disseminated hellp hemostasis hepatitis hepatology icp intravascular management nonpalpable
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... • Reduced liver ... • Massive hemorrhage ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... #diagnosis #causes
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
imaging: Hepatic ... extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... obstetrics #hepatitis #comparison ... #differential #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... red to purple, hemorrhagic ... deficiency • Liver ... Cholesterol emboli • Septic ... Vasculopathy #Purpura #Differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... Acquired: • Heparin ... intravascular coagulation ... discern these causes
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