14 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... • Reduced liver ... • Massive hemorrhage ... #diagnosis #differential
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... obstetrics #hepatitis #comparison ... #differential # ... diagnosis #icp #
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... , Metastasis #Liver ... #Lesions #Hepatic ... POCUS #radiology #differential ... #diagnosis #comparison
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... phosphatase sources: - Highest ... • Bone • Liver ... Intestine - Other causes ... elevation DDX of Hepatic
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... #Coagulation #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... Acquired: • Heparin ... discern these causes ... #Diagnosis #Hematology
Appearance of Liver Lesions on Contrast Enhanced Ultrasound - Early arterial, Grayscale phase, Late arterial phase,
Appearance of Liver ... Contrast Enhanced Ultrasound ... #Lesions #Hepatic ... POCUS #radiology #differential ... #diagnosis #comparison
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... red to purple, hemorrhagic ... deficiency • Liver ... #Diagnosis #hematology
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage ... - Differential ... Diagnosis and Management ... CBC, fibrinogen, PT ... compression (using ultrasound