5 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... • Massive hemorrhage
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
imaging: Hepatic ... extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... obstetrics #hepatitis #comparison ... #differential #
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... #treatment #management
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage ... - Differential ... Diagnosis and Management ... CBC, fibrinogen, PT ... compression (using ultrasound