13 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... • Reduced liver ... • Massive hemorrhage ... #hematology #coagulation
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential ... #hematology #coagulation
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... #Lesions #Hepatic ... POCUS #radiology #differential ... #diagnosis #comparison ... table #appearance #hepatology
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
ultrasound: A concerning ... reflection on the differential ... of air in the hepatic ... variety of other causes ... #hepatology #liver
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
phosphatase sources: - Highest ... • Bone • Liver ... Intestine - Other causes ... elevation DDX of Hepatic ... Diagnosis #Algorithm #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Acral cyanosis • Hemorrhagic ... DIC • Severe Liver ... #treatment #management ... #hematology
Appearance of Liver Lesions on Contrast Enhanced Ultrasound - Early arterial, Grayscale phase, Late arterial phase,
Appearance of Liver ... Contrast Enhanced Ultrasound ... POCUS #radiology #differential ... #diagnosis #comparison ... table #appearance #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... Acquired: • Heparin ... discern these causes ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology