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Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... Hemopathies+++: Hodgkin ... Drugs, Unknown cause
Differential Diagnosis of Fever and Splenomegaly - Typhoid - Infective endocarditis - Miliary tuberculosis - Hodgkin
Differential Diagnosis of Fever ... tuberculosis - Hodgkin ... Brucellosis #Fever ... Differential #Diagnosis #causes
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma ... of about three cases ... Lymphoma - Clinical ... • Dyspnea • Fever ... Lymphoma (90-95% of cases
The many faces of the Hodgkin/Reed-Sternberg (HRS) cell: Even as medical students we are aware of
many faces of the Hodgkin ... seen in every case ... of classical Hodgkin ... TheLymphomaniac #Hodgkins ... cell #Pathology #Clinical
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Hodgkin's Lymphoma ... vs Non-Hodgkin's ... Autoimmune diseases • Clinical ... - Pel-Ebstein fever ... Noncontiguous spread • Clinical
Faget's Sign & Liebermeister's Rule Pulse-Temperature Dissociation EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM INFECTIOUS
BPM INFECTIOUS CAUSES ... OTHER CAUSES ... CLINICAL UTILITY ... There are specific cases ... #differential #causes
Faget Sign - Pulse-Temperature Dissociation Causes of Relative Bradycardia • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Dissociation Causes ... • Infectious Causes ... , Typhoid fever, ... Non-Infectious Causes ... differential #diagnosis #causes
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
Causes of Fever ... Neoplasm: • NHL • Hodgkin's ... Other: • Drug fever ... • Factitious fever ... Diagnosis #Algorithm #causes
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... #bradycardia #Causes
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... Non-Infectious Causes ... 1-2 weeks • Hodgkin
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