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Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Hemopathies+++: Hodgkin ... Drugs, Unknown cause ... 100 mg/m2) : in case ... Lymphohistiocytosis #diagnosis #management
Differential Diagnosis of Fever and Splenomegaly
 - Typhoid
 - Infective endocarditis
 - Miliary tuberculosis
 - Hodgkin
Differential Diagnosis of Fever ... tuberculosis - Hodgkin ... Brucellosis #Fever ... Differential #Diagnosis #causes
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma ... of about three cases ... • Dyspnea • Fever ... Lymphoma (90-95% of cases ... hematology #oncology #management
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Hodgkin's Lymphoma ... vs Non-Hodgkin's ... Comparison Hodgkin's ... - Pel-Ebstein fever ... , Hodgkin Lymphomas
The many faces of the Hodgkin/Reed-Sternberg (HRS) cell: Even as medical students we are aware of
many faces of the Hodgkin ... seen in every case ... of classical Hodgkin ... TheLymphomaniac #Hodgkins
Treatment Approach to Hodgkin's Lymphoma

By Matthew Ho, MD PhD @MatthewHoMD
With Credit: Dr Sunita Nasta and Dr
Treatment Approach to Hodgkin's ... guidelines #Hodgkins ... oncology #Hematology #management
Faget Sign - Pulse-Temperature Dissociation
Causes of Relative Bradycardia
 • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Dissociation Causes ... • Infectious Causes ... , Typhoid fever, ... Non-Infectious Causes ... differential #diagnosis #causes
Faget's Sign & Liebermeister's Rule
Pulse-Temperature Dissociation
EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM
INFECTIOUS
BPM INFECTIOUS CAUSES ... • Typhoid Fever ... OTHER CAUSES ... There are specific cases ... #differential #causes
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm
Neoplasm:
• NHL
• Hodgkin's lymphoma
• Leukemia
• Solid
Causes of Fever ... Neoplasm: • NHL • Hodgkin's ... Other: • Drug fever ... • Factitious fever ... Diagnosis #Algorithm #causes
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... #bradycardia #Causes