13 results
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Agents to Treat Hyperkalemia ... magnesium, and calcium ... patients sensitive to high ... Potassium #Binding #Hyperkalemia ... #pharmacology #table
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
Hypercalcemia Evaluation ... PTH - Frankly high ... BrighamChiefs #Hypercalcemia ... #workup #differential ... endocrinology #calcium
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
abnormalities - Hypercalcemia ... Hypomagnesemia #Differential ... Low #Magnesium #Table ... #Classification ... #Causes #Workup
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
• LDH ↑ • Hyperkalemia ... /Late - Hypercalcemia ... UA positive for blood ... potassium and calcium ... Dialysis for severe hyperkalemia
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Can give with blood ... Is Dangerous in Hyperkalemia ... shift • Saline Causes ... densa receives high ... • Saline May Cause
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... and Differential ... with previously stable ... Hyperthyroidism, Hypercalcemia ... #causes #Differential
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pump - Digoxin works ... causes: - Increased ... - Hyperkalemia ( ... high potassium levels ... Because digoxin binds
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia
Unexplained increase in ETCO2 AND tachycardia AND increased
other, more common causes ... with dantrolene Hyperkalaemia ... : calcium chloride ... Hyperthermia #Crisis #Anesthesiology ... Diagnosis #Management #Workup
Intraoperative  Bradycardia - Guidelines for Crises in Anaesthesia
Bradycardia in theatre should not be treated as
Consider known drug causes ... Also consider: high ... beta-blocker; digoxin; calcium ... myocardial infarction, hyperkalaemia ... Diagnosis #Management #Workup
Cardiac Arrest - Guidelines for Crises in Anaesthesia

The probable cause is one or more of: something
Hypovolaemia Hypo/hyperkalaemia ... 3-5) Massive blood ... CardiacArrest #Checklist #Differential ... #Anesthesiology ... Diagnosis #Management #Workup