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Hypercalcemia Workup and Differential Diagnosis Framework
1) Determine whether PTH-dependent
2) Assess for other hormonal causes
3) Assess for
Hypercalcemia Workup ... and Differential ... uw_IMresidency #Hypercalcemia ... #Workup #Differential ... Diagnosis #algorithm #endocrinology
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
abnormalities - Hypercalcemia ... - Hypokalemia ... #Differential # ... Magnesium #Table #Classification ... #Causes #Workup
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Hyperparathyroidism • Hypercalcemia ... Hyperparathyroidism • Hypercalcemia ... MultipleEndocrineNeoplasia #Differential ... #Endocrinology ... #Classification
Diagnostic algorithm for the workup of hypercalcemia. The diagnostic workup for patients presenting with hypercalcemia rests
of hypercalcemia ... presenting with hypercalcemia ... hypocalciuric hypercalcemia ... #Diagnosis #Hypercalcemia ... #Workup #Differential
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
Hypercalcemia Evaluation ... BrighamChiefs #Hypercalcemia ... #workup #differential ... #diagnosis #endocrinology ... elevated #evaluation #workup
Causes of Hypermagnesemia
Increased magnesium load
 - Magnesium-containing laxatives, antacids, or enemas
 - Treatment of pre-edampsia/eclampsia (mothers
Causes of Hypermagnesemia ... or enemas - Treatment ... hypocalciuric hypercalcemia ... Addison's disease) #Hypermagnesemia ... Causes #diagnosis #differential
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... Milk-alkali syndrome #Hypercalcemia ... #Causes #endocrinology ... #diagnosis #differential
Hypokalemia - Differential Diagnosis
Poor Intake 
 - Starvation
 - Anorexia
GI Losses 
 - Vomiting / NG
Hypokalemia - Differential ... - Polyuria - Hypomagnesemia ... Alkalosis - Marked cell ... DrEricStrong #Hypokalemia ... Potassium #Table #Classification
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
causes (e.g., hypokalemia ... , hypercalcemia) ... , Sickle cell disease ... Treatment is aimed ... Nephrology #Diagnosis #Differential
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
• LDH ↑ • Hyperkalemia ... Hyperphosphatemia • Hypocalcemia ... /Late - Hypercalcemia ... kidney tubular cells ... Dialysis for severe hyperkalemia