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sepsis diagnosis ebm evidence improve interventions matter outcomes septic septicshock
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
monocyte dysfunction/hypofunction ... injury: Glycocalyx loss ... CAUSES + RISK FACTORS ... • Risk factors ... INITIAL MANAGEMENT
Sepsis - Interventions that do / do not improve outcomes Do: - Have high index of suspicion and
sepsis pathway or protocol ... persistent septic shock ... noradrenaline - Lots ... Interventions #Management ... #EBM #Effectiveness
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