25 results
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
Pathophysiology ... Ketoacidosis (DKA) and Hyperglycemic ... deficit: - Type I DM ... produced - Type II DM ... #dka #hhs #pathophysiology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
agent • Does not cause ... hypoglycemia ... mL/minute/1.73 m2 ... e.g. diarrhea, nausea ... Pharmacology #Summary #DM2
Diabetes – diabetic nephropathy
Majority of the literature in the area is applied to the diabetic nephropathy
- Chronic hyperglycemia ... be the primary cause ... hyperfiltration - Hyperglycemia ... - Cytokines #Pathophysiology
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm
Lifestyle  Modifications (Diet and Exercise) -> Start
Recurrent severe hypoglycemia ... relative with DM2 ... associated with DM ... • Secondary Causes ... Management #algorithm #DM2
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
Pathyophysiology ... - hyperglycemic ... crises in patients
Central Retinal Vein Occlusion (CRVO)
 - Pathophysiology not fully understood; possibly due to thrombus located in
Occlusion (CRVO) - Pathophysiology ... Second most common cause ... disease (Most common cause ... ) #Clinical #Ophthalmology
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
- Overview and Pathophysiology ... why LR does not cause ... Impaired O2 Delivery (DO2 ... differential #diagnosis #pathophysiology
Mydriasis and Miosis - Differential Diagnosis Framework

Causes of Mydriasis:
Dilated pupils (mydriasis) more than 7mm
 • Unilateral
Diagnosis Framework Causes ... Hypothermia Causes ... Robertson pupils), DM ... differential #diagnosis #ophthalmology ... #causes
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... ascites, jaundice, hypoglycemia ... diagnosis #management #pathophysiology
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
hyalinization causes ... BRB breakdown causes ... disc arterioles causes ... #Retinopathy #pathophysiology ... #ophthalmology