Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS) Absolute Insulin deficit: - Type I DM: No insulin produced - Type II DM pts under large stresses that ↑ insulin demand Relative Insulin deficit: - inadequate production, insulin resistance, non-adherence to insulin TX, stresses ↑ Insulin demand: infections, food binges, etc Hyperglycemia → Glucosuria → Polyuria → Dehydration → Electrolyte imbalance → Polydipsia #dka #hhs #pathophysiology #comparison #endocrinology #diabetes #diabetic #ketoacidosis #hyperglycemic #hyperosmolar
