37 results
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... and sodium • Dosing ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Potassium Excretion ... ACE inhibitors, ARBs ... happypillsrx/ #Hyperkalemia ... Pathophysiology #Pharmacology ... #Renal
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
Monitor BP, potassium ... , and renal function ... ACEInhibitor #ACEIs #Dosing ... #Conversion #Pharmacology ... PrimaryCare #Comparison #Table
Hypokalemia - Differential Diagnosis
Poor Intake 
 - Starvation
 - Anorexia
GI Losses 
 - Vomiting / NG
Hypokalemia - Differential ... Mineralocorticoid excess - Renal ... Diagnosis #Low #Potassium ... #Table #Classification ... #Causes
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Clenching of fist during ... • Recent IV potassium ... deficiency • Renal ... differential #diagnosis #causes ... #potassium #high
Classification, Differential Diagnosis, and Features of Hyponatremia According to Volume Status 

Hypervolemic hypernatremia 
 - CHF
Glucocorticoid deficit - Hypokalemia ... Drugs - SIADH Renal ... deficit - Salt-losing ... Differential #Diagnosis #Table ... #Causes
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
oxoproline) • Renal ... Renal acidosis ... Hypokalemia ... Potassium-sparing ... ACE-Is and ARBs
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Clenching of fist during ... • Recent IV potassium ... deficiency • Renal ... differential #diagnosis #causes ... #potassium #high
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
) MECHANISM: Potassium ... oral suspension DOSING ... patiromer) is a potassium ... inhibitors, etc.) are ... #Pharmacology
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
sodium, which causes ... inhibiting drug classes ... Aliskiren, ACEI, ARB ... avoid harmful hyperkalemia ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology