14 results
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Cerebral Salt Wasting ... Neurological event 2) Sodium ... Hypovolaemia → ADH ... diagnosis #nephrology #hyponatremia ... #comparison
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
: • ADH ON (UOsm ... OFF (UNa > 30): SIADH ... Reset osmostat, Cerebral ... salt wasting • ADH ... Algorithm #diagnosis #sodium
Hyponatremia - Differential Diagnosis by Mechanism
Decr Blood Pressure (“Decr Effective Circulating Volume”) 
 - Volume depletion
Hyponatremia - Differential ... Inappropriate ADH ... secretion (SIADH ... osmostat - Cerebral ... Table #Causes #Sodium
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Utilizing Uric Acid ADH ... Osmolarity 3) Urine Sodium ... Low Uric Acid → SIADH ... #Differential #
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
restriction alone in SIADH ... Present (Uosm ≥100): SIADH ... , Renal Sodium loss ... Insufficiency, Cerebral ... #differential #
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
Hyponatremia - Differential ... • UOsm > 300 - ADH ... , SSRIs) - SIADH ... #Differential # ... diagnosis #nephrology #sodium
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
body water in comparison ... osmolality helps to differentiate ... consequence of cerebral ... #hyponatremia #ADH ... EBV #potomania #SIADH
A lazy man's classification of hyponatremia
There are two possible approaches to the diagnosis of hyponatremia: .
classification of hyponatremia ... osmolality and urinary sodium ... the patient has SIADH ... or cerebral salt ... #Algorithm #Differential
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
majority of cases, ADH ... approach to the differential ... 2) Is ADH elevated ... #Differential # ... management #nephrology #sodium
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... promoting passive sodium ... antagonists: • Blocks ADH ... #Management #hyponatremia ... #nephrology #treatment