9 results
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... PBC Signs and Symptoms ... & AST normal or ... obstruction • ALP ... #workup #hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
suspicious clinical symptoms ... presence of metabolic syndrome ... alcohol-related liver disease ... non-alcoholic fatty liver disease ... #Algorithm #Hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Malnutrition • Wilson's disease ... • hypothyroidism ... collection with EDTA Pathophysiology ... mineralization Symptoms ... Hyophosphatasia #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... - Symptoms of ... upper limit of normal ... Hepatitis (eg Viral) Management ... #Management #Hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... ATRA treatment Pathophysiology ... : >3 symptoms, or ... #management #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
regarding the diagnosis ... suspected HH based on symptoms ... causes of liver disease ... including liver and hematologic ... #management #hepatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... involve one, two, or all ... Myeloproliferative Disease ... low and appear abnormal ... #diagnosis #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... ingestion • B symptoms ... number of sites of disease ... classification #hematology ... #oncology #management
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
cell lymphoma Pathophysiology ... and the systemic symptoms ... Histopathological Diagnoses ... phosphatase - Normal ... #management #rheumatology