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diagnosis differential rheumatology types allergy dermatology hypersensitivity pathophysiology petechiae petechial rash reactions table anemia causes comparison cryoglobulinemia cryoglobulins em erythematosus
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... antibiody -> Immune Complex ... Formation - Complement ... > Incr Immune Complex ... TerrierBen #Hypocomplementemic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... Coronary arteries - Fever ... : • Fevers • ... against MPO • Complement ... #rheumatology #classification
Algorithm for the differentiation between simple and complex febrile seizures. Guidelines for evaluation of each. #Diagnosis
Algorithm for the ... between simple and complex ... FebrileSeizure #Fever ... #Workup #Simple ... #Complex
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
immunofluorescence Immune Complex ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Fevers • Fatigue ... and branches • Fever ... pauci-immune GN Immune Complex ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Anaphylaxis, Hay fever ... Antigen-antibody complex ... Antigen-antibody complexes ... they activate complement ... allergy #table #classification
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Purpuric Rashes- THE ALGORITHMIC ... ; however, an algorithmic ... petechiae/purpura with fever ... petechiae/purpura with fever ... petechiae require complete
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • Low serum C4 complement ... • IgA vasculitis ... • Vasculitis ... diagnosis #types #classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
, seasonal hay fever ... antigen, leading to complement ... Antigen-antibody complexes ... Complement activation ... Hypersensitivity #Types #Classification
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... Infection - Vasculitis ... Red Flags: • Fever ... deficiency Work ... Up: • Complete
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