Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a) -> Anaphylatoxins, Chemokines, Cytokines, Mast Cells -> Incr Vascular Permeability, Chemotaxis -> Vascular and perivascular inflammatory cells -> Incr Immune Complex Formation -> Vasculitis + Tissue Damage Dr. Benjamin Terrier @TerrierBen #Hypocomplementemic #Urticarial #Vasculitis #HUV #Pathophysiology #Rheumatology
