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diagnosis rheumatology differential cryoglobulins gammopathy glomerulonephritis mgrs monoclonal progressive rapidly renal rpgn significance types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Lupus Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis ... immunotactoid GN, cryoglobulinemic
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