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diagnosis rheumatology differential management classification druginduced glomerulonephritis nephrology nephrotic testing comparison cryoglobulinemia cryoglobulins dermatology dil disease erythematosus initial nephritic nephritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... - Skin, glomeruli ... such as systemic lupus ... against MPO • Complement ... , and SLE) • Urinalysis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... Discontinuation of causal ... • Immunologic Workup ... 80% - Low complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... • Immunologic Workup ... Positive in 60-80% of cases ... 80% - Low complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... (e.g. systemic lupus ... erythematosus (SLE
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... #testing #workup
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... • Kidneys: Non-glomerular ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Differential Diagnosis Algorithm ... Infection - Vasculitis ... (lupus, RA, Sjogren's ... deficiency Work
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... #workup #diagnosis
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... 90% - Low complement ... Discontinuation of causal
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