12 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... - CHAMPS Mnemonic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #CHAMPS #Mnemonic
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... • Vasculitis ... diagnosis #types #classification
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... periumbilical region), nausea ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
SPEP+free light chains ... SPEP+free light chains ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... SPEP+free light chains ... SPEP+free light chains ... infections are common causes ... for ANCA-related vasculitis
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... activation (↓ cAMP ... #Pharmacology #Classification ... #Classes #pathophysiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Vaughan Williams Classification ... activation (↓ cAMP ... #Pharmacology #Classification ... #Classes #pathophysiology