11 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... - CHAMPS Mnemonic ... Chain deposition disease ... 1 (50%-80%), type ... #Low #Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... antigen, leading to complement ... during hemolytic disease ... Complement activation ... #Types #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
of hypersensitivity ... Allergen-specific lgE causes ... reaction, Haemolytic disease ... they activate complement ... allergy #table #classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... #classification
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). 

IgA Nephropathy is the most common cause of
(i.e Berger’s Disease ... the most common cause ... - What type of Hypersensitivity ... Relationship of complement ... PediatricNephrology #Hypersensitivity
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
for glomerular disease ... or alternative complement ... infections are common causes ... of glomerular disease ... cryoglobulinemias (types
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
for glomerular disease ... or alternative complement ... SPEP+free light chains ... infections are common causes ... cryoglobulinemias (types
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm
Lifestyle  Modifications (Diet and Exercise) -> Start
Type 2 Diabetes ... and Management Algorithm ... • Secondary Causes ... PCOS), Pancreatic Disease ... #DM2 #DMII #Classification
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
caused by nephrotoxic ... Clinical Clues: ... guide subtype classification ... tubulopathy) - Complement ... vasculitis Types