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diagnosis rheumatology glomerular nephrology testing workup cryoglobulinemia cryoglobulins diabetes disease dm2 dmii erythematosus gammopathy glomerulonephritis igg4 initial lupus lymphoproliferative mgrs
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... hematological disorders ... • Low serum C4 complement ... #classification
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... cryoglobulinemias (types ... glomerulonephritis #nephrotic ... #nephritic #nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... ) • Endocrine disorders ... Kikuchi disease • Type-I ... RNP antibodies, Complement
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... cryoglobulinemias (types ... testing #nephrology #nephrotic ... #nephritis
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Lymphoproliferative Disorders ... Diagnosis and classification ... to 50% of PTLD cases ... Lymphoproliferative #Disorders ... oncology #diagnosis #management
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm Lifestyle Modifications (Diet and Exercise) -> Start
Type 2 Diabetes ... Diagnosis and Management ... Algorithm Lifestyle ... • Secondary Causes ... #DMII #Classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
• Pancreas: Type ... Tubulointerstitial nephritis ... - ↑ IgE, ↓ complement ... • Classification ... IGG4 #Diagnosis #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... IV RTA, TYPE I ... • Interstitial nephritis ... Rheumatology #Diagnosis #Management
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... or plasma cell disorder ... guide subtype classification ... tubulopathy) - Complement ... vasculitis Types
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