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rheumatology differential allergy hypersensitivity management reactions disease erythematosus hematology lupus sle table agglutinin allergic anca anemia causes champs cold comparison
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Type Ill - IgG and ... Complement activation ... #Classification ... Pathophysiology #Allergy #Diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... 1 (50%-80%), type ... glomerulonephritis (>90%) S - Systemic ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Diagnosis # ... IM #Rheum #Vasculitis ... #Vessel #Size #Classification ... #Differential #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Labs/Diagnosis: ... • Low serum C4 complement ... disorder (e.g. systemic ... #types #classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
- Mediators: IgG ... Mechanism of Action: IgG ... they activate complement ... glomerulonephritis, Systemic ... allergy #table #classification
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
female, asian • Systemic ... PET-CT Imaging (→ Diagnostic ... rheumatoid factor), ± hypocomplementemia ... No necrosis, No vasculitis ... Related #Disease #diagnosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Mediator: IgM + IgG ... Immunological Mediator: IgG ... complexes • Ex: Systemic ... #Classification ... #Diagnosis #Definitions
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
• Pancreas: Type ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification ... -4 #IGG4 #Diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... or anti-ß2GPI IgG ... anticoagulant • Complement ... Erythematosus #diagnosis
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