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A System for Vasculitides 

#Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Small #Medium ... #Large #Vessel # ... Size #Classification ... #Differential #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
abnormalities SMALL ... , arthritis LARGE ... Vessel Size: • Large ... against MPO • Complement ... #rheumatology #classification
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... of large vessels ... central nervous system ... small vessels ... disease - systemic
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... • Cutaneous small-vessel ... disorder (e.g. systemic ... diagnosis #types #classification
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
discrepancies LARGE ... and infarcts SMALL ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic ... chorioretinitis, CNS large
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... multiple organs, small-vessel ... large-vessel vasculopathy ... Arterial (MCC-small ... Medium and large
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... inflammation of the small ... and large bowel
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Musculoskeletal system ... nodules are slightly larger ... Leukocytoclastic vasculitis ... examination of small
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... : small-fiber neuropathy ... ) • Cutaneous vasculitis ... Vasculitis: • ... cell lymphoma • Large