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diagnosis differential nephrology rheumatology hematology renal management nephrotic aki glomerulonephritis hematuria proteinuria anemia nephritic pulmonary syndrome syndromes table testing types
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... - Skin, glomeruli ... : - Kidneys: glomerular ... against MPO • Complement ... #rheumatology #classification
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Causes of Hematuria - Glomerular vs Non-glomerular == Glomerular == - Glomerulonephritis - Thin basement membrane disease ==
Causes of Hematuria ... basement membrane disease ... Polycystic kidney disease ... #Algorithm #Diagnosis ... Nonglomerular #Causes
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Kidney Injury - Classification ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... tubular necrosis (causes ... Kidney #Injury #Classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... of Glomerular Bleeding ... basement membrane disease ... Diagnostic of GN or vasculitis ... disease Renal
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... formation along glomerular ... staining (lg + complement ... MGPN • Complement ... (Dense deposit disease
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... RBC casts in urine ... diabetes)) #Glomerular ... #Diseases #Nephritic ... Nephrotic #Syndromes #Classification
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Differential Diagnosis Algorithm ... • Thin GBM disease ... • Pauci-immune disease ... #Causes
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease ... • Kidneys: Non-glomerular ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
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