Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria) - Mesangial hypercelluIarity - Endocapillary proliferation • Double contour formation along glomerular capillary walls Immune-Complex Mediated • "Full house" IF staining (lg + complement) • Ex: HCV, HBV, Sjogren's, rheumatoid arthritis, monoclonal gammopathy Complement-Mediated MGPN • Complement deposition without lg on IF • Dysregulation and activation of alternative complement pathway • C3 glomerulopathy (Dense deposit disease, C3GN, CFHR5 neph) MPGN without complement of lg deposition • Minimal immune deposits on EM, negative IF • Ex: Thrombotic microangiopathy (TMA), anti-phospholipid syndrome, post-bone marrow transplantation, transplant glomerulopathy, radiation nephritis, malignant HTN #Membranoproliferative #Glomerulonephritis #MPGN #nephrology #diagnosis #renal
