23 results
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Pathogenesis and Clinical ... (GD-IgA1). ... Activation of complement ... especially knees and ankles
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen - IgG ... or IgM antibody ... antigen, leading to complement ... Complement activation ... Hypersensitivity #Types #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
- Mediators: IgG ... / IgM - Antigen ... antigens, leading to complement ... they activate complement ... allergy #table #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Erythematosus Clinical ... or anti-ß2GPI IgG ... anticoagulant • Complement ... #EULARACR #Classification
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). 

IgA Nephropathy is the most common cause of
pathogenesis of IgA ... IgA Nephropathy ... Relationship of complement ... to IgA Nephropathy ... BergersDisease #clinical
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulins are Igs ... Syndrome: • Clinical ... • Low serum C4 complement ... • IgA vasculitis ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Schonlein Purpura (IgA ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Idiopathic monoclonal IgM ... Viral Infection Clinical ... Immunoglobulin M (IgM ... Donath-Landsteiner (IgG ... temperatures by fixing complement
Forrest Classification for Peptic Ulcer Bleeding
Rebleeding risks are without endoscopic intervention
1a - Spurting Bleed - 60-100%
Forrest Classification ... 50% Re-bleeding IIa ... Re-bleeding #Forrest #Classification ... gastroenterology #EGD #clinical
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
Pathogenesis and clinical ... autoimmune antibodies (IgG ... , rarely IgM) against ... activates the complement