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Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... - Local and systemic ... , seasonal hay fever ... Complement activation ... #Types #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
table of types of hypersensitivity ... Allergen-specific lgE causes ... Anaphylaxis, Hay fever ... glomerulonephritis, Systemic ... allergy #table #classification
Shock - Differential Diagnosis by Classification
Reflex Syncope 
 - Vasovagal syncope
   • Prolonged standing
Shock - Differential ... Diagnosis by Classification ... Carotid sinus hypersensitivity ... • Multiple system ... #Table #Causes
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... Coronary arteries - Fever ... Vasculitis: • Fevers ... against MPO • Complement ... #rheumatology #classification
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Fevers ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic ... inflammation Hypersensitivity
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... diagnosis #types #classification
Modified dengue severity classification, PAHO/WHO
Dengue without warning signs - DNWS:
 • Person who lives or has
dengue severity classification ... days and presents fever ... Shock or respiratory ... Shock evidenced ... central nervous system
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm
Structural Defect - Asplenia/HypospIenism
 • Bacteremia/Septic
Causes of Fever ... Bacteremia/Septic Shock ... Periodontal Disease Complement ... Infection #Fever ... #Causes #Hematology