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diagnosis differential rheumatology nephrology glomerular glomerulonephritis hematology nephrotic testing workup acute aki champs cryoglobulins dermatology disease fever gammopathy immunecompromised immunocompromised
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Lupus Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Differential Diagnosis Algorithm ... insufficiency • Vasculitis ... Thalessemia • Cryoglobulinemia ... Differential #Diagnosis #Algorithm ... #causes
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
, Distributive Shock ... Emboli, Thrombosis, Vasculitis ... Diagnosis #nephrology #causes ... #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... factor - Screen for cryoglobulinemias
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... factor - Screen for cryoglobulinemias
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... : • 7%, Cryoglobulinemia
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