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diagnosis rheumatology differential comparison lupus vasculitis allergy reactions systemic causes champs clinicopathology compared criteria cryoglobulinemia cryoglobulins dermatology druginduced erythemas eularacr
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... Systemic Lupus Erythematosus ... #Low #Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... Complement activation ... systemic lupus erythematosus ... #Types #Classification ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... types of hypersensitivity ... Systemic lupus erythematosus ... #allergy #table ... #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... vasculitis • Hypersensitivity ... systemic lupus erythematosus ... (SLE), rheumatoid ... #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Systemic Lupus Erythematosus ... > 0.5 g/24 hr, Class ... anticoagulant • Complement ... #Criteria #SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... RNP antibodies, Complement
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... 90% - Low complement ... Systemic Lupus Erythematosus ... 80% - Low complement ... #comparison #table
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... systemic lupus erythematosus ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
form of delayed-type ... hypersensitivity ... presenting with erythematous ... HSV + Mycoplasma classic ... Erythemas #comparison #table
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... ischemia • Skin: Erythematous ... tract, and often causes ... Vasculitis) • Hypocomplementemic ... inflammation Hypersensitivity
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