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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Urticaria and hypocomplementemia ... - (C-ANCA) pattern ... - (P-ANCA) pattern ... against MPO • Complement ... #rheumatology #classification
Nodular pattern
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary TB: random nodules
3. Sarcoidosis: nodules with perilymphatic
Nodular pattern ... Hypersensitivity ... Hypersensitivity ... CTChest #Nodular #Pattern ... #Comparison #Table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... types of hypersensitivity ... types #allergy #table ... #classification ... #comparison
On the left some diseases with a nodular pattern.
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary
with a nodular pattern ... Hypersensitivity ... Hypersensitivity ... #Differential #Comparison ... #Table #RadiologyAssistant
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... antigen, leading to complement ... Complement activation ... #Types #Classification ... Diagnosis #Reactions #Table
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... • IgA vasculitis ... • Hypersensitivity ... vasculitis • ... diagnosis #types #classification
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... white and gray matter ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic ... inflammation Hypersensitivity
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
of delayed-type hypersensitivity ... of necrotizing vasculitis ... PrathitKulkarni #Erythemas #comparison ... #table #differential
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Why Does MGRS Matter ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis