19 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... Discontinuation of causal ... • Immunologic Workup ... 80% - Low complement
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... erythematosus (SLE ... #classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of types ... Allergen-specific lgE causes ... antigens, leading to complement ... they activate complement ... allergy #table #classification
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... • Immunologic Workup ... Positive in 60-80% of cases ... 80% - Low complement
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
Diagnosis and workup ... What type of MNCD ... Alzheimer - 1st cause ... Dementia - 2nd cause ... Differential #Subtypes #Classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... again we might see ... #typea #typeb # ... classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... RNP antibodies, Complement
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... cryoglobulinemias (types ... glomerular #testing #workup