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diagnosis differential rheumatology classification pulmonary causes champs cryoglobulinemia cryoglobulins erythematosus glomerulonephritis hematology hemoptysis massive mimics mnemonic progressive rapidly renal rpgn
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Diagnosis Framework Diffuse ... ANCA Associated Vasculitis ... anti-GBM) 10%: - Low ... Complement Levels ... - Normal Complement
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Differential Diagnosis Algorithm ... • Bronchitis Diffuse ... • Pulmonary Vasculitis ... Malignancy Pulmonary Vasculitis ... • Lupus Erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... pneumonitis • Diffuse ... enteropathy, and diffuse ... , lymphopenia, low
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
factor level • Low ... serum C4 complement ... • IgA vasculitis ... • Vasculitis ... (e.g. systemic lupus
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