7 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... - Local and systemic ... Complement activation ... arthritis, and systemic ... lupus erythematosus
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
table of types of hypersensitivity ... they activate complement ... glomerulonephritis, Systemic ... lupus erythematosus ... classification #comparison
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... 90% - Low complement ... months to years) Systemic ... 80% - Low complement ... #sle #comparison
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
Differential Diagnosis Algorithm ... lung as nodules Hypersensitivity ... - Immunologic (hypersensitivity ... Rheumatoid Arthritis, Systemic ... Lupus and Scleroderma
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... lupus erythematosus ... against MPO • Complement
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... disorder (e.g. systemic ... lupus erythematosus