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diagnosis rheumatology differential disease hematology nephrology table vasculitis workup allergy causes erythematosus glomerular glomerulonephritis hypersensitivity laboratory nephritis nephrotic potassium reactions
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... S - Systemic Lupus ... #Low #Complement
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification Algorithm ... #Lupus #Nephritis ... #Classification ... #differential #types
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... C3 or low C4, Low ... C3 and low C4 ... #EULARACR #Classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... , and systemic lupus ... #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of types ... antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic lupus ... allergy #table #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Hypokalemia - Differential Diagnosis Poor Intake - Starvation - Anorexia GI Losses - Vomiting / NG
tubular acidosis (Types ... and 2, but not type ... 4) - Salt wasting ... Differential #Diagnosis #Low ... Potassium #Table #Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... factor level • Low ... serum C4 complement ... (e.g. systemic lupus ... #classification
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... #Deficiency #Testing ... #Algorithm #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
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