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diagnosis rheumatology classification allergy differential hypersensitivity management reactions table champs comparison cryoglobulinemia cryoglobulins erythematosus glomerular hematology huv hypersensitivityreaction hypocomplementemic igg4
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... S - Systemic Lupus ... #Low #Complement
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Post-strep GN, Lupus ... #Vasculitis #differential ... #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus ... Classification #Pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... Types: • Type ... • Low serum C4 complement ... • Vasculitis ... (e.g. systemic lupus
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... : • Systemic Lupus ... Post-infectious glomerulonephritis ... sickness #TypeIII #Type3 ... Allergy #Immunology #pathophysiology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of types ... antigens, leading to complement ... they activate complement ... Post-streptococcal glomerulonephritis ... , Systemic lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... ANCA-associated vasculitis ... Kikuchi disease • Type-I ... • Mesenteric vasculitis ... RNP antibodies, Complement
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
or alternative complement ... for ANCA-related vasculitis ... cryoglobulinemias (types ... workup #diagnosis #glomerulonephritis
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