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diagnosis rheumatology treatment types vasculitis allergy cardiology comparison cryoglobulinemia cryoglobulins differential endocarditis erythematosus hemophagocytic hlh hypersensitivity indications infections infectiousdiseases leishmaniasis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Summary • Epidemiology ... Positive in 60-80% of cases ... 80% - Low complement ... #Summary #rheumatology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... Anaphylaxis, Hay fever ... they activate complement ... allergy #table #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Vasculitis: • Fevers ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Visceral Leishmaniasis - Diagnosis and Management Summary Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi Where: South Asia, East
Diagnosis and Management ... Summary Species ... Neutralization of complement ... 2-6 months • Fever ... Weight Loss • Can cause
Summary of Infections in which Steroids play a role in treatment • TB meningitis • TB
Summary of Infections ... pericarditis (select cases ... infection per se ... Severe typhoid fever ... Indications #infections #management
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Endocarditis Summary ... • Autoimmune (SLE ... night sweats, fever ... Persistent bacteremia/fevers ... Endocarditis #diagnosis #management
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