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diagnosis rheumatology differential vasculitis erythematosus lupus systemic anemia champs clinicopathology criteria cryoglobulins deficiency eularacr gammopathy glomerulonephritis hemolytic laboratory low management
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #differential #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... • Low serum C4 complement ... erythematosus (SLE ... diagnosis #types #classification ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Lupus Nephritis, Cryoglobulinemia ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ANCA +MPO) • Cryoglobulinemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... vasculitis, and SLE ... #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... pericarditis • Hematologic ... anticoagulant • Complement ... #EULARACR #Classification ... #Criteria #SLE
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... suspicion for complement ... #Deficiency #Testing ... #Algorithm #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... RNP antibodies, Complement
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... genotypes): SS, SC, SE ... Differential #Diagnosis #Algorithm ... #workup #hematology ... #testing
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... / ANCA + MPO) Cryoglobulinemic ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic ... Differential #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Cytopenia: 2% • Hypocomplementemia ... Nephrogenic DI Hematologic ... Vasculitis: • 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology
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